Andre Stennette-Harrod, 21, and his older half-brother, LaVonne Harrod, 24, were killed in a car at the intersection of 38th Street and Georgetown Road, about a block away from Cloud 9, where they had attended a concert, RTV6's Eboné Monet reported.
"This is just a senseless, senseless murder," said Sabrina Stennette, Andre's mother.
Friends flooded the brothers' Facebook and Twitter accounts with condolences. Andre would have started his senior year at Ball State University this fall.
"It's devastating to see your son at 11 o'clock that night and hug them and tell them you love them, and the next thing you hear is that he's gone over something senseless," Stennette said.
Rapper Yo Gotti was the performer at the show. He tweeted that the club was so packed that the fire marshal came to shut it down.
Stennette said Andre and his brother were good men and that her son started a business using basketball to counter street violence.
"They are taking lives for no reason, and whoever did, I just want you to know that you didn't just impact him, but he has family that loves him. He has people who love him, and he had a dream to stop this madness," Stennette said. "He was promoting using basketball to get kids off the street and … away from violence, and then it's violence that takes his life."
Police have not made any arrests or released any information about possible suspects. Investigators put out a call for information that could lead to an arrest.
"Detectives continue to track down witnesses and evaluate physical evidence in an attempt to identify a suspect or suspects, but believe several people could have witnessed the actual shooting or circumstances that led up to the shooting," said Indianapolis police spokesman Kendale Adams.
Police asked anyone with information to call Crime Stoppers at 317-262-TIPS